3D printed T1D treatment?

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To achieve that high density, Perrier and his colleagues 3D printed islets from a “bioink” made of human pancreatic tissue and alginate, a type of carbohydrate derived from seaweed. Live insulin-producing cells were mixed into this material.

“We put this bioink with the [human] islet into a syringe, and we print a special motif [with it],” says Perrier. This porous grid is designed to allow new blood vessels to grow around and through the structure.

In the lab, this technique “works very well”, says Perrier, noting that about 90 per cent of the islets’ cells survived and functioned for up to three weeks. “The next challenge is really to validate this finding in vivo.” Perrier and his colleagues presented their research at the European Society for Organ Transplantation (ESOT) 2025 meeting in London on 29 June.

exertions plus AI

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After two years of diminshing returns of running – thanks to nuHerbie's insulin pumping – I wanted to switch things up and, lo, this first morning of a new workout routine, thanks to Claude AI. Can't overstate the amount of help Claude's been here: it's been amazing to have an analytical compliment who, when given my exact needs and insulin requirements, can generate a workout routine that will replace daily running while doing things that I've already been doing AND condense those into one long morning session (in this case, 40 minutes of yoga, 35 minutes of muay thai (swapped in for boxing to make up for the loss of leg motion without running, followed by a 10-minute cooldown yoga session). We made a few changes to incorporate "exit points" in the event of hypoglycemic moment, but other than that, this has been great - especially the change in my CGM arc from a crashing tidal wave to a gentle climb and gentle landing. Tomorrow is the same routine, but with HIIT instead of muay thai, while the next day is a strength and running combo. A most welcome change.

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And we're back to sub-mile daily runs wrought by blood sugar crashes. First time since I started running 12 years ago that I ran the first route, "around the block," that got me started. Wanting to believe that it's an omen of my rebuilding back to my daily 5k (I've given up hope of ever reaching my once-daily 10k in this, the age of NuHerbie) but I'd rather stuff my face with pink Starburst right now TYVM. Another insulin decrease duly initiated.

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First run of more than a half a mile in days. Usually aim for a 5k every day, but as per standard T1D practices, weather and a sudden downshift in insulin requirements (not that I'm complaining) over the last several days precluded me being anything but a glucose-tablet-and/or-pink-Starburst-stuffing mess after more than half a mile. Managed a little over two miles this morning which hopefully signals that nuHerbie's dialed in to the new, decreased requirements and drip-drip of life. Hopefully I’ll make it back to 5k+ this week though who knows.

rain rain rain rain wind wind wind wind advisory advisory advisory blah blah blah

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Indeed, it is rainy and windy. Again.

Week's been nuts so my efforts to work out a rhythm to the day remain elusive. Assuming, as per usual, that I'll find it just as I have to switch to summer break schedule. Alternative would be to give in, start sb schedule now so I'm less pissy when the time comes. Hopefully sticking to Project500 (more on that in Sunday's Macro0166 but please do know know that "Project500" isn't some stupid / clever code title for something: I literally don't have a name for it and I'm basing it around 500 words, so that's what it'll be for now) / TSBMR / MacroParentheticals and that being it will help.

Current Project500 quandary: what's the bare minimum needed to open the gate to the winding road through?

High potassium continues, though all other numbers look fine, except for blood sugar but that's not surprising; it's always high in the morning. Doubtful that I have kidney disease, though who knows at this point. Only dietary thing I can think of that I've added (other than weight) since my big checkup (where everything was peachy) in December, is matcha (which I'm not giving up because I like how it makes me feel - read: not comatose) and an extra vitamin D3 pill at the doc's request three days a week. Everything they suggested had MORE potassium than what I was doing so fuck it, IDK. No call yet from the whitecoats, though if they keep to their pattern, it'll be either at lunch or at the end of the day.

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Blood sacrifice made but, more importantly, on the drive in, listening to The White Stripes, three ideas: One, that I want to take more of a songwriting approach to writing my weird shit by which I mean a more write it and move approach; I love the feel of things like that sound like a creative explosion – The Beatles's White Album, the oeuvre of Jack White, etc – and less a polished thing (novels, screenplays, etc). Second, I shouldve made a five year plan in the vein of Cal Newport’s SLOW PRODUCTIVITY ten years ago; better late than never, I suppose. And finally, I really fucking hate this switch back to cold because my blood sugar is out of control and it pisses me off which makes it even more out of control. But, ah, matcha: that stuff really is great.